LOBULAR BREAST CANCER
Using the causal event of E-cadherin loss as a starting point, we study how ILC cells control their anchorage independence, cell cycle regulation, and invasive and metastatic phenotype.
We ultimately aim at translation of our results into daily pathological diagnosis and treatment.
Over the past 20 years, our work has helped to lay a biochemical foundation for three clinical phase intervention trials specifically for ILC.
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THE ONCOGENIC TYROSINE KINASE FER
In high grade cancers such as Triple Negative Breast Cancer and Head & Neck cancer, FER is a late progression factor promoting multiple oncogenic events through the control over endosomal sorting and recycling. Furthermore, FER has revealed itself as a predictive factor for Taxane benefit in high rist Breast Cancer. Clinical conformation efforts are currently ongoing using retrospective and new prospective trial data. We study FER in high risk breast and head & neck cancer.
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