News and Published data
A nuclear mechano-sensitive mechanism controlling YAP
We co-author on work from the Roca-Cusachs lab showing that a laminin-Integrin β4-keratin link prevents nuclear deformation and YAP signals. Published in NATURE MATERIALS and sponsored by our H2020-FET MechanoControl.eu consortium.
A NEW CANCER ASSOCIATED EXON IN TLN1 (TALIN)
Ben Goult’s lab a discovered a cancer associated exon in the Talin-1 gene (TLN1). Data are now published in the JOURNAL OF CELL BIOLOGY Thijs Koorman in the DerksenLab contributed to the cancer bits and bobs.
SKOR1 controls breast cancer invasion
Lilian and Sandra identified a new FER kinase substrate called SKOR1 that praomotes breast cancer invasion. Results are published in the JOURNAL OF CELL SCIENCE, and our image is featured on the cover!
A NEW MOUSE cancer MODEL
Eline and Thijmen published a new mouse model for inducible skin and mammary cancer in NEOPLASIA, based on conditional knockout of E-cadherin and p53 through inducible LGR6 expression.
RSPO IN BREAST CANCER
Eline published data in the JOURNAL OF PATHOLOGY showing that R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer! A fruitful collaboration with the John Hilkens group @ NKI/AvL.
Id2 underpins Indolent ILC
Them Id2 Boys Max Rätze and Thijs Koorman have figured out (well, at least in part) why ILC is a low grade disease! Work instigated by lab alumnus Robert van de Ven has culminated in a publication in ONCOGENE.
uncoupling bundling and stiffness
Thijs Koorman’s LOXL3 paper is out in ONCOGENE! We show that ductal breast cancer, in contrast to ILC, use Loxl3 to spatially stiffen the ECM for collective invasion.
The end-all-be-all of ILC histology
OUT NOW! In the context of a special edition on Lobular Breast Cancer in CANCERS
An idc wannabe forming tubules
P-cadherin Switching in ILC is out in Modern Pathology! We co-author on this work, showing that P-cadherin is the molecular determinant of a mixed-appearing histomorphology in ILBCs with tubular elements.