News and Published data
Our team co-authors on this wonderful work published in J PATHOL where Gronewold et al. demonstrate restoration of junctional characteristics in metastatic ILC cells to the colon. Stromal signals at work??
Ben Goult’s lab a discovered a cancer associated exon in the Talin-1 gene (TLN1). Data are now published in the JOURNAL OF CELL BIOLOGY Thijs Koorman in the DerksenLab contributed to the cancer bits and bobs.
Lilian and Sandra identified a new FER kinase substrate called SKOR1 that promotes breast cancer invasion. Results are published in the JOURNAL OF CELL SCIENCE, and our image is featured on the cover!
Eline and Thijmen published a new mouse model for inducible skin and mammary cancer in NEOPLASIA, based on conditional knockout of E-cadherin and p53 through inducible LGR6 expression.
Eline published data in the JOURNAL OF PATHOLOGY showing that R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer! A fruitful collaboration with the John Hilkens group @ NKI/AvL.
Them Id2 Boys Max Rätze and Thijs Koorman have figured out (well, at least in part) why ILC is a low grade disease! Work instigated by lab alumnus Robert van de Ven has culminated in a publication in ONCOGENE.
Thijs Koorman’s LOXL3 paper is out in ONCOGENE! We show that ductal breast cancer, in contrast to ILC, use Loxl3 to spatially stiffen the ECM for collective invasion.
OUT NOW! In the context of a special edition on Lobular Breast Cancer in CANCERS
P-cadherin Switching in ILC is out in Modern Pathology! We co-author on this work, showing that P-cadherin is the molecular determinant of a mixed-appearing histomorphology in ILBCs with tubular elements.