A nuclear mechano-sensitive mechanism controlling YAP

We co-author on work from the Roca-Cusachs lab showing that a laminin-Integrin β4-keratin link prevents nuclear deformation and YAP signals. Published in NATURE MATERIALS and sponsored by our H2020-FET MechanoControl.eu consortium.
(September 2023)

INAUGURAL LECTURE PROF. DR. PWB DERKSEN

Patrick accepted his full professorship and gave his inaugural lecture called “A Tailored Intervention for Cancer (Research)” on the 21st of April. You can find the video here and the written format here.
(May 2023)

SKOR1 controls breast cancer invasion

Lilian and Sandra identified a new FER kinase substrate called SKOR1 that praomotes breast cancer invasion. Results are published in the JOURNAL OF CELL SCIENCE, and our image is featured on the cover!
(February 2023)

A NEW MOUSE cancer MODEL

Eline and Thijmen published a new mouse model for inducible skin and mammary cancer in NEOPLASIA, based on conditional knockout of E-cadherin and p53 through inducible LGR6 expression.
(November 2022)

RSPO IN BREAST CANCER

Eline published data in the JOURNAL OF PATHOLOGY showing that R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer! A fruitful collaboration with the John Hilkens group @ NKI/AvL.
(November 2022)

Id2 underpins Indolent ILC

Them Id2 Boys Max Rätze and Thijs Koorman have figured out (well, at least in part) why ILC is a low grade disease! Work instigated by lab alumnus Robert van de Ven has culminated in a publication in ONCOGENE.
(June 2022)

FER controls the cancer endosome

Check out Sandra Tavares‘ paper in CELL REPORTS on FER kinase, its DIRECT targets, control over fast endosomal recycling, and predictive value in breast cancer.
(June 2022)

uncoupling bundling and stiffness

Thijs Koorman’s LOXL3 paper is out in ONCOGENE! We show that ductal breast cancer, in contrast to ILC, use Loxl3 to spatially stiffen the ECM for collective invasion.
(March 2022)

IDC? ILC? DuctolObular?

Christgen et al. are at it again! Cover art in the JOURNAL OF PATHOLOGY. E-cadherin expression as a diagnostic standard for ILC. An absolute no-brainer that should be Globally implemented!
(February 2022)

The end-all-be-all of ILC histology

OUT NOW! In the context of a special edition on Lobular Breast Cancer in CANCERS
(August 2021)

An idc wannabe forming tubules

P-cadherin Switching in ILC is out in Modern Pathology! We co-author on this work, showing that P-cadherin is the molecular determinant of a mixed-appearing histomorphology in ILBCs with tubular elements.
(June 2020)

the lobsterpot is alive!

Support for the ELBCC-instigated oncology task forces for ILC. See the details on the ELBCC website and sign up if you want to join this at the EU COST Portal for our action (CA19138).
Follow @ELBCC on twitter using #LOBSTERPOT and #CA19138.