Scientific output | PUBMED Citations 

Haughton PD, Haakma W, Chalkiadakis T, Breimer GE, Driehuis E, Clevers H, Willems S, Prekovic S, Derksen PWB.
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer
Oncogene. 2024 Aug;43(32):2463-2474. doi: 10.1038/s41388-024-03091-4. Epub 2024 Jun 28. PMID: 38942893

Khalil AA, Smits D, Haughton PD, Koorman T, Jansen KA, Verhagen MP, van der Net M, van Zwieten K, Enserink L, Jansen L, El-Gammal AG, Visser D, Pasolli M, Tak M, Westland D, van Diest PJ, Moelans CB, Roukens MG, Tavares S, Fortier AM, Park M, Fodde R, Gloerich M, Zwartkruis FJT, Derksen PW*, de Rooij J*.
A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion
Nat Commun. 2024 Jun 7;15(1):4866. doi: 10.1038/s41467-024-49230-z. PMID: 38849373

Geukens T, et al. (Collab Desmedt lab @KU Leuven)
Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program
NPJ Breast Cancer. 2024 Apr 24;10(1):31. doi: 10.1038/s41523-024-00637-3. PMID: 38658604

De Schepper M, Koorman T, Richard F, Christgen M, Vincent-Salomon A, Schnitt SJ, van Diest PJ, Zels G, Mertens F, Maetens M, Vanden Bempt I, Harbeck N, Nitz U, Gräser M, Kümmel S, Gluz O, Weynand B, Floris G, Derksen PWB*, Desmedt C*; Pathology Working Group of the European Lobular Breast Cancer Consortium.
Integration of Pathological Criteria and Immunohistochemical Evaluation for Invasive Lobular Carcinoma Diagnosis: Recommendations From the European Lobular Breast Cancer Consortium
Mod Pathol. 2024 Jul;37(7):100497. doi: 10.1016/j.modpat.2024.100497. Epub 2024 Apr 17. PMID: 38641322

Gronewold M, et al. (Collab Christgen lab @Hannover Medical School)
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon.
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361. PMID: 38618992

Van Baelen K, et al. (Collab Desmedt lab @KU Leuven)
Reporting on invasive lobular breast cancer in clinical trials: a systematic review.
NPJ Breast Cancer. 2024 Mar 20;10(1):23. doi: 10.1038/s41523-024-00627-5. PMID:38509112 

Sijnesael T, Richard F, Rätze MA, Koorman T, Bassey-Archibong B, Rohof C, Daniel J, Desmedt C, Derksen PW.
Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type.
J Pathol. 2023 Dec;261(4):477-489. doi: 10.1002/path.6205. Epub 2023 Sep 22. PMID: 37737015

Kechagia Z, et al.. (Collab Roca-Cusachs lab @IBEC)
The laminin-keratin link shields the nucleus from mechanical deformation and signalling.
Nature Materials. 2023 Nov;22(11):1409-1420. doi: 10.1038/s41563-023-01657-3. PMID: 37709930 

Gallego-Paez LM et al. (Collab with Goult lab @Kent).
TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity.
J Cell Biol. 2023 May 1;222(5):e202209010. doi: 10.1083/jcb.202209010. Epub 2023 Mar 6. PMID: 36880935 

Sluimer LM, Bullock E, Rätze MAK, Enserink L, Overbeeke C, Hornsveld M, Brunton VG, Derksen PWB, Tavares S.J
SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells.
J Cell Sci. 2023 Feb 1;136(3):jcs260243. doi: 10.1242/jcs.260243. Epub 2023 Feb 6. PMID: 36620935

Ter Steege EJ, Sijnesael T, Enserink L, Klarenbeek S, Haakma WE, Bakker ERM, Derksen PWB.
LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice.
Neoplasia. 2022 Nov 10;35:100844.  doi: 10.1016/j.neo.2022.100844. PMID: 36371908 

Ter Steege EJ, Boer M, Timmer NC, Ammerlaan CM, Song JY, Derksen PW, Hilkens J, Bakker ER.
R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer.
J Pathol. 2022 Nov;258(3):289-299. doi: 10.1002/path.5999. Epub 2022 Sep 15. PMID: 36106661 

van der Velden LM, et al. (Collab Strous/Klumperman lab @UMCU)
Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis.
Front Endocrinol. 2022 Jul 28;13:926210. doi: 10.3389/fendo.2022.926210. eCollection 2022. PMID: 35966052 

Schepper M, et al. (collab. Desmedt lab @KU Leuven)
Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer.
Ann Oncol. 2022 May 20:S0923-7534(22)01167-X. doi: 10.1016/j.annonc.2022.05.006. PMID: 35605746 

Rätze MAK*, Koorman T*, Sijnesael T, Bassey-Archibong B, van de Ven R, Enserink L, Visser D, Jaksani S, Viciano I, Bakker ERM, Richard F, Tutt A, O’Leary L, Fitzpatrick A, Roca-Cusachs P, van Diest PJ, Desmedt C, Daniel JM, Isacke CM, Derksen PWB.
Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer.
Oncogene. 2022 May;41(21):2932-2944. doi: 10.1038/s41388-022-02314-w. Epub 2022 Apr 18. PMID: 35437308 

Tavares S, Liv N, Pasolli M, Opdam M, Rätze MAK, Saornil M, Sluimer LM, Hengeveld RCC, van Es R, van Werkhoven E, Vos H, Rehmann H, Burgering BMT, Oosterkamp HM, Lens SMA, Klumperman J, Linn SC, Derksen PWB. 
FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer.
Cell Reports. 2022 Apr 5;39(1):110584. doi: 10.1016/j.celrep.2022.110584. PMID: 35385742

Koorman T, Jansen KA, Khalil A, Haughton PD, Visser D, Rätze MAK, Haakma WE, Sakalauskaitè G, van Diest PJ, de Rooij J, Derksen PWB.
Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment.
Oncogene. 2022 Mar 15. doi: 10.1038/s41388-022-02258-1. PMID: 35292774

Christgen M, et al. (collab. Lobsterpot)
Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma.
J Pathol Clin Res. 2022 Mar;8(2):191-205. doi: 10.1002/cjp2.253. Epub 2021 Dec 10. PMID: 34889530 

Sflomos G et al. (collab. Lobsterpot)
Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions.
Cancers (Basel). 2021 Oct 27;13(21):5396. doi: 10.3390/cancers13215396. PMID: 34771558 

Christgen  M, et al. (collab. Lobsterpot) 
Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors
Cancers (Basel). 2021 Jul 22;13(15):3695.  doi: 10.3390/cancers13153695. PMID: 34359596

Christgen M, Bartels S, Luttikhuizen J, Bublitz J, Rieger LU, Christgen H, Stark H, Sander B, Lehmann U, Steinemann D, Derksen PW, Kreipe H.
E-cadherin to P-cadherin Switching in Lobular Breast Cancer With Tubular Elements.
Mod Pathol. 2020 Jun 22. doi: 10.1038/s41379-020-0591-3. PMID: 32572153

Teo K, Gómez-Cuadrado L, Tenhagen M, Byron A, Rätze M, van Amersfoort M, Renes J, Strengman E, Mandoli A, Singh AA, Martens JH, Stunnenberg HG, van Diest PJ, Brunton VG, Derksen PWB.
E-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancer.
Sci Rep. 2018 Oct 18;8(1):15454. doi: 10.1038/s41598-018-33525-5. PMID: 30337563

Oudenaarden CRL, van de Ven RAH, Derksen PWB.
Re-inforcing the cell death army in the fight against breast cancer.
J Cell Sci. 2018 Aug 23;131(16). pii: jcs212563. doi: 10.1242/jcs.212563. Review. PMID: 30139926

de Groot JS, Rätze MAK, van Amersfoort M, Eisemann T, Vlug EJ, Niklaas MT, Chin SF, Caldas C, van Diest PJ, Jonkers J, de Rooij J, Derksen PWB. 
αE-catenin is a candidate tumor suppressor for the development of E-cadherin expressing lobular-type breast cancer.
J Pathol. 2018 May 17. doi: 10.1002/path.5099. PMID: 29774524

Bajrami I, ..Derksen PWB, Jonkers J, Tutt ANJ, Ashworth A, Lord CJ.
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.
Cancer Discov. 2018 Apr;8(4):498-515 PMID: 29610289

Hornsveld M, .. Derksen PWB, Burgering BMT, Dansen TB.
FOXO transcription factors both suppress and support breast cancer progression.
Cancer Res. 2018 Feb 12. PMID: 29440168

Kievit A, .. Derksen PWB, .. van Haaften G.
Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome.
Eur J Hum Genet. 2018 Feb;26(2):210-219. PMID: 29348693

Derksen PWB, van de Ven RAH. 
Shared mechanisms regulate spatiotemporal RhoA-dependent actomyosin contractility during adhesion and cell division. 
Small GTPases. 2017 Dec 31:1-9. PDF | PMID: 29291271

de Groot JS, van Diest PJ, Derksen PW. 
Prophylaxis of hereditary breast cancer. 
Aging (Albany NY). 2017 Dec 8;9(12):2453-2454. PDF | PMID: 29227964

Hornsveld M, Dansen TB, Derksen PW, Burgering BMT. 
Re-evaluating the role of FOXOs in cancer. 
Semin Cancer Biol. 2017 Nov 21. pii: S1044-579X(17)30090-1. doi: 10.1016/j. PDF | PMID: 29175105

Raap M, .. Derksen PW, .. Christgen M. 
Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2β. 
Lab Invest. 2017 Oct 16. doi: 10.1038/labinvest.2017.106. PMID: 29035379

de Groot JS, van Diest PJ, van Amersfoort M, Vlug EJ, Pan X, Ter Hoeve ND, Rosing H, Beijnen JH, Youssef SA, de Bruin A, Jonkers J, van der Wall E and Derksen PWB.
Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice.
Oncotarget. 2017 Jun 15. PDF | PMID: 28644128

Bruner HC and Derksen PW. 
Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer.
Cold Spring Harb Perspect Biol. 2017 May 15. PMID: 28507022 

van de Ven RA, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PW. 
p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.
Nat Commun. 2016 Dec 22;7:13874. PDF| PMID: 28004812

Bouchet BP, Noordstra I, van Amersfoort M, Katrukha EA, Ammon Y-C, ter Hoeve ND, Hodgson L, Dogterom M, Derksen PW,  Akhmanova A. Mesenchymal Cell Invasion Requires Cooperative Regulation of Persistent Microtubule Growth by SLAIN2 and CLASP1. 
Dev Cell. 2016 Dec 8. PMID: 27939686 

Tenhagen M, Klarenbeek S, Braumuller TM, Hofmann I, van der Groep P, Ter Hoeve N, van der Wall E, Jonkers J, Derksen PW.
p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice. 
J Mammary Gland Biol Neoplasia. 2016 Jul 13.  PMID: 27411687

Hornsveld M, Tenhagen M, van de Ven RA, Smits AM, van Triest MH, van Amersfoort M, Kloet DE, Dansen TB, Burgering BM, Derksen PW. 
Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancer. 
Cell Death Differ. 2016 Apr 1. PMID: 27035620 

van Brussel AS, .. Derksen PW, .. van Bergen En Henegouwen PM. 
Hypoxia-Targeting Fluorescent Nanobodies for Optical Molecular Imaging of Pre-Invasive Breast Cancer. 
Mol Imaging Biol. 2015 Nov 20. PMID: 26589824

Moelans CB, Vlug EJ, Ercan C, Bult P, Buerger H, Cserni G, van Diest PJ, Derksen PW. 
Methylation biomarkers for pleomorphic lobular breast cancer – a short report. 
Cell Oncol (Dordr). 2015 Sep 21. PMID: 26392358

Van de Ven RAH, Tenhagen M, Meuleman W, van Riel JJG, Schackmann RCJ, Derksen PW.
Nuclear p120-catenin regulates anoikis resistance of Lobular Breast Cancer through Kaiso-dependent Wnt11 expression.
Dis Model Mech.; 2015 Feb 20. PDF | PMID: 25713299

Christgen M, Derksen PW.
Lobular breast cancer: molecular basis, mouse and cellular models. 
Breast Cancer Res. 2015 Feb 8;17(1):491. PMID: 25757734

Ivanova IA, Vermeulen JF, Ercan C, Houthuijzen JM, Saig FA, Vlug EJ, van der Wall E, van Diest PJ, Vooijs M, Derksen PW.
FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance.
Oncogene. 2013. 32(50):5582–92. PMID: 23873028

Vlug EJ, van de Ven RAH, Vermeulen JF, Bult P, Diest PJ, Derksen PW.
Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer.
Cell Oncol (Dordr). 2013. 36(5):375–84. PMID: 23949920

Schackmann RCJ, Tenhagen M, van de Ven RAH, Derksen PW.
p120-catenin in cancer – mechanisms, models and opportunities for intervention.
J Cell Sci. 2013. 126(16):3515–25.  PMID: 23950111

Schackmann RCJ, Klarenbeek S, Vlug EJ, Stelloo S, van Amersfoort M, Tenhagen M, Braumuller TM, Vermeulen JF, van der Groep P, Peeters T, van der Wall E, Van Diest PJ, Jonkers J, Derksen PW.
Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling.
Cancer Res. 2013. 73(15):4937–49. PMID: 23733751

Vermeulen JF, van Brussel ASA, Adams A, Mali WPTM, van der Wall E, Van Diest PJ, Derksen PW.
Near-infrared fluorescence molecular imaging of ductal carcinoma in situ with CD44v6-specific antibodies in mice: a preclinical study.
Mol Imaging Biol. 2013. 15(3):290–8. PMID: 23184608

Vermeulen JF, van de Ven RAH, Ercan C, van der Groep P, van der Wall E, Bult P, Christgen M, Lehmann U, Daniel J, Van Diest PJ, Derksen PW.
Nuclear Kaiso expression is associated with high grade and triple-negative invasive breast cancer.
PLoS ONE. 2012;7(5):e37864.  PMID: 22662240

Daenen LGM, Roodhart JML, van Amersfoort M, Dehnad M, Roessingh W, Ulfman LH, Derksen PW, Voest EE. Chemotherapy enhances metastasis formation via VEGFR-1-expressing endothelial cells.
Cancer Res. 2011.71(22):6976–85.

Roodhart JML, .. Derksen PW, .. Voest EE.
Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids.
Cancer Cell. 2011. 20(3):370–83.

Schackmann RCJ, van Amersfoort M, Haarhuis JHI, Vlug EJ, Halim VA, Roodhart JML, Vermaat JS, Voest EE, van der Groep P, Van Diest PJ, Jonkers J, Derksen PW.
Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance.
J Clin Invest. 2011. 121(8):3176–88.  PDF|PMID: 21747168

Derksen PW, Braumuller TM, Van Der Burg E, Hornsveld M, Mesman E, Wesseling J, Krimpenfort P, Jonkers J.
Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice.
Dis Model Mech. 2011. 4(3):347–58.  PDF| PMID: 21282721

Beerling E, Ritsma L, Vrisekoop N, Derksen PWB, Van Rheenen J.
Intravital microscopy: new insights into metastasis of tumors.
J Cell Sci. 2011 Feb 1;124(Pt 3):299–310. 

Hoogwater FJH, .. Derksen PW, .. Kranenburg O.
Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.
Gastroenterology. 2010. 138(7):2357–67. 

Evers B, .. Derksen PW, .. de Visser KE.
A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis.
J Pathol. 2010. 220(1):34–44. PMID: 19927317

Xian W, .. Derksen PW, .. Brugge JS.
Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival.
Cancer Res. 2009. 69(6):2244–51. 

Rottenberg S, .. Derksen PW, .. Jonkers J.
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
Proc Natl Acad Sci U S A. 2008. 105(44):17079–84. 

Lehembre F, .. Derksen PW, .. Christofori G.
NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin.
EMBO J. 2008. 27(19):2603–15.  

Evers B, .. Derksen PW, .. Jonkers J.
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.
Clin Cancer Res. 2008. 14(12):3916–25. 

Jonkers J, Derksen PW.
Modeling metastatic breast cancer in mice.
J Mammary Gland Biol Neoplasia. 2007. 12(2-3):191–203.  PDF | PMID: 17587153

Derksen PW, Liu X, Saridin F, Van Der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A, Jonkers J.
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.
Cancer Cell. 2006. 10(5):437–49.  PDF| PMID: 17097565

Tjin EPM, .. Derksen PW, .. Spaargaren M.
Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma.
Blood. 2006. 107(2):760–8.  

Tjin EPM, Bende RJ, Derksen PW, van Huijstee A-P, Kataoka H, Spaargaren M, Pals ST.
Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator.
J Immunol. 2005. 175(5):2807–13.  

Tjin EPM, Derksen PW, Kataoka H, Spaargaren M, Pals ST.
Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator.
Blood. 2004. 104(7):2172–5.  

Derksen PW, Tjin E, Meijer HP, Klok MD, Mac Gillavry HD, van Oers MHJ, Lokhorst HM, Bloem AC, Clevers H, Nusse R, van der Neut R, Spaargaren M, Pals ST.
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.
Proc Natl Acad Sci USA. 2004. 101(16):6122–7.  PDF| PMID: 15067127